Victims of a bus accident are treated; two doctors join the rotation; O'Hara is happy spending time with her son; Akalitus gives Eddie his job back.
Kevin demands full custody; a bus crash patient returns after contracting sepsis; Coop threatens to quit.
After their custody meeting, Jackie rear-ends Kevin and wakes up as a patient in her own ER. Kevin accuses her of using. Coop begins covering for Carrie and taking on a lot more work. When Carrie checks on Jackie, she writes her a prescription for Oxy, unaware she's an addict. The most unlikely person asks Jackie out on a date.
A heavily medicated Jane Doe is brought into the ER and Jackie tasks Zoey with finding out who she is. Coop invites Carrie to dinner. Jackie faces conflict with both her daughters - Fiona has been acting out in class while Grace sneaks around the city with her older boyfriend.
Jackie is nervous about her date with Frank, so Zoey and Thor help her get ready and Eddie offers some friendly pointers. Prentiss misdiagnoses an injured dancer, but Akalitus and Coop catch his mistake before the patient leaves. Mike Cruz calls Jackie in a moment of need.
Jackie and Grace recover from their nights of indiscretion; Carrie uses flashcards to strengthen her skills.
Akalitus forgets to hire an escort for a psych patient who then lays waste to the pharmacy; Frank cancels a lunch date with Jackie; Zoey hears Coop and Carrie having sex; Jackie worries about Frank when she learns that a cop has been shot.
What clearly is going to be "the night" for Jackie and Frank is interrupted by Kevin, figuring she was at work. Kevin is apologetic, but Jackie is angry; Akalitus's blood results are in; Zoey helps Prentiss organize his disaster of an office; In a moment of panic, Carrie makes the right diagnosis on a patient who cannot breathe; Jackie attends an AA meeting; Jackie and Grace get into a fight after Jackie discovers Grace left campus for lunch. Jackie is convinced that Grace is sneaking behind her back to see Danny, but Grace assures her they broke up.
Kaum haben Jackie und ihr neuer Schwarm Frank die erste Nacht miteinander verbracht, entfährt ihm ein „Ich liebe dich!“. Jackie ist davon sichtlich irritiert. Doch dann überschlagen sich die Ereignisse: Kevin hat Tabletten im Rucksack ihrer Tochter Grace gefunden. Hat Jackie tatsächlich einen schlechten Einfluss auf ihre Töchter?
Jahrestag: Krankenschwester Jackie ist nun seit einem Jahr clean. Doch ihre Tochter weigert sich strikt zu ihrer Feier zu kommen und ihr Freund Frank ist sauer, dass sie bei dem Chaos nicht sein Geschenk aufgemacht hat. Im Krankenhaus gibt Jackie einem schwulen Patienten die letzte Ölung. Anschließend feiert Jackie ihren Jahrestag auf ihre ganz eigenen Art.