Staffel 1

Dr. Grace Devlin will die Spielschulden ihres Bruders abbezahlen und wird so zur Ärtin der Chicagoer Mafia. Ihre Verpflichtung beginnt mit einer furchtbaren Aufgabe - sie soll einen Patienten töten, der als Mafia-Informant im Zeugenschutzprogramm kurz vor einer Aussage gegen die Mafiabosse steht.

Constantine arrangiert ein Treffenfür Grace mit Morettis früheren Rivalen, der sich in einem schlechten Gesundheitszustand befindet. Außerdem behandeln GRace und Brett eine junge Braut mit emotionalen Problemen.

Grace (Jordana Spiro) kümmert sich um die Opfer eines tödlichen Autounfalls, ist jedoch schockiert darüber, dass sie auch den flüchtigen Fahrer des unfallverursachenden Wagens behandlen soll. Unterdessen landet eine Nachbarin von Grace nach einer Kneipenschlägerei in der geschlossenen Psychiatrie. Nate (Jesse Lee Soffer) trifft eine Entscheidung aus taktischem Kalkül.

Dr. Grace Devlin (Jordana Spiro) muss das Leben eines alten Freundes retten, der während einer Kneipentour verletzt wurde. Außerdem soll sie in Contantines Auftrag das Baby eines schwangeren Mädchens entbinden. Franco muss für seinen Boss den Aufenthaltsort einer jungen Frau ausfindig machen.

Während Grace (Jordana Spiro) für die Herztransplantation ihrer chronisch kranken Patientin (Laura Breckenridge) kämpft, soll sie in Consantines (William Forsythe) Auftrag den entfremdeten Vater der Patientin umbringen um das Organ zu bekommen, das ihr Leben retten könnte.

Emotions reach a breaking point when Grace and Brett's relationship shows signs of strain due to their demanding and hectic schedules. Meanwhile, Grace finds herself in a perilous situation when mob boss Paul Moretti (Michael Rapaport) takes matters into his own hands.

When two innocent bystanders are caught up in an ambush meant for Franco and the rest of Moretti's crew, Grace joins the action. As the war between Moretti (Michael Rapaport) and Constantine escalates, Grace makes a critical move in an attempt to end the feud.

In an attempt to form a coalition of mob factions, Constantine enlists Celeste LaPree (Jennifer Beals), his old girlfriend and former call girl-turned-madam, now married to a hypochondriac mafia boss who runs Chicago's Northside. Meanwhile, Franco has a shocking revelation for Grace, forcing her to make some pivotal decisions about love and loyalty.

When Franco tells master thief Russell King (Michael Madsen), who is in Chicago for a big heist, to show up at Roosevelt Medical and request Dr. Devlin's treatment for a flare-up of back pain, it's discovered that he needs immediate surgery. Meanwhile, Constantine becomes suspicious when he learns that Russell has resurfaced on his turf. An intense race against time for Grace, Constantine and Russell unfolds as the lucrative crime looms and lives are on the line.

Spirits intensify at Roosevelt Medical Center when Dr. Devlin and Dr. Robinson treat a priest who was bitten in the face during an exorcism of a demon. After Constantine learns that newcomer Russell King (Michael Madsen) has his eye on taking over downtown, he consults Celeste (Jennifer Beals) and Al Trapani (Mike Starr) to help him evaluate the risks and rewards of consolidating the power in Chicago. Meanwhile, Dr. Devlin dives deeper into the fold when Nate calls her into action to aide a runaway who may have witnessed a murder.

When a champagne bomb is delivered to Constantine, he and Celeste (Jennifer Beals) go on high alert to determine who wants him dead. Meanwhile, Nate turns to Grace after he accidentally jeopardizes a mobster's valuable racehorse. Back at Roosevelt Medical Center, Grace is tapped to treat Brett's estranged brother, Jack Hanson (Derrick Trumbly), following a severe cycling accident.

As Constantine attempts to reconnect with his estranged son Garrett, who is deep in debt to the ruthless Nogales Cartel, he enlists the help of his Chicago mob colleague, Al Trapani (Mike Starr). As payback for the favor, Constantine orders Grace to diagnose Trapani’s girlfriend, a patient with a shocking secret who is experiencing inexplicable pains.

Grace's world crumbles as her family remains in jeopardy, the FBI closes in and Constantine reveals something that rocks her to the core. Meanwhile, longtime mobster Al Trapani (Mike Starr) becomes increasingly involved in Constantine's business, and Franco's secret leaks. As the walls begin to close in on Grace and the duality of her life cuts deeper than ever before, she makes a desperate attempt to settle her role in both worlds in the series finale.